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What is MTP Kit? How to use MTP Kit? How Does It Works?

What is MTP Kit?

MTP Kit USA contains 1 tablet of Mifepristone 200 mg and 4 tablets of Misoprostol 200 mg. Mifepristone is to be taken orally and Misoprostol is to be given vaginally for the medical termination of pregnancy. It should be taken up to 63 days, or 9 weeks.

How to use MTP Kit?
MTP Kit is prescribed to women for the medical termination of intrauterine pregnancy of up to 9 weeks gestation based on the first day of amenorrhea or last menstrual period. For this treatment, pregnancy is dated from the first day of amenorrhea in a presumed 28-day cycle, with ovulation occurring at mid-cycle. It is important to determine the duration of pregnancy from menstrual history and by clinical examination. If the duration of pregnancy is uncertain, ultra-sonogram (USG) scan should be used. USG can also be used if ectopic pregnancy is suspected.

Before using the kit, any type of intrauterine device (IUD) must be removed. If MTP Kit fails, pregnancy termination by surgery is advised to cause intrauterine pregnancy termination.

Mifepristone is administered by a gynecologist after assessing the gestational age of the fetus or to diagnose ectopic pregnancies. The gynecologist should also be able to perform the surgical intervention in cases of severe bleeding or incomplete abortion.



Using MTP Kit: Appropriate Dosage

The dosage of mifepristone is 200 mg orally followed by misoprostol 800 mcg (4 tablets of 200 mcg) vaginally after three days. Misoprostol may be administered vaginally by a trained medical professional or it can also be self-administered by the woman. If abortion has not occurred within 4 hours of administration of misoprostol, a second dose of misoprostol 400 mg may be administered orally or vaginally.

Usually, the patient using MTP Kit should return for a follow-up visit after 14 days of administration. This is to confirm that a complete pregnancy termination has occurred with the help of a clinical examination or USG scan. There is a risk of fetal malformation if the patients have an ongoing pregnancy at this follow-up visit. In such a case, surgical termination is recommended.

How does MTP Kit Works?

Mifepristone is a synthetic steroid that has an anti-progesterone effect, which results in the termination of pregnancy. It antagonizes the myometrium and endometrium effects of progesterone. During pregnancy, Mifepristone sensitizes the myometrium to the contraction, inducing prostaglandin action. It allows the dilatation and opening of the cervix. Mifepristone also has an anti-glucocorticoid and weak anti-androgenic effect.

Misoprostol is a synthetic prostaglandin, a potent antagonist of gastric acid secretion in humans. It softens the cervix and contracts the uterus. Misoprostol causes myometrial contractions, initiating muscle contraction. And by interacting with prostaglandin receptors, it softens the cervix and contracts the uterus to contract, leading to the expulsion of the contents in the uterus.


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